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Article

The many faces of RET dysfunction in kidney

1 Oct 2009

Abstract excerpt

Signaling pathways that are activated upon interaction of glial cell-line derived neurotrophic factor (Gdnf), its coreceptor Gfra1, and receptor tyrosine kinase Ret are critical for kidney development and ureter maturation. Outside the kidney, this pathway is implicated in a number of congenital diseases including Hirschsprung disease (intestinal aganglionosis, HSCR) and hereditary cancer syndromes (MEN 2). Total...

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Identifiers

PMID: 20539737
DOI: 10.4161/org.5.4.10048

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