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Article

Critical and distinct roles for key RET tyrosine docking sites in renal development.

Genes & development - 1 Feb 2006

Jain Sanjay, Encinas Mario, Johnson Eugene M, Milbrandt Jeffrey

Abstract excerpt

Molecular mechanisms that lead to congenital anomalies of kidneys and the lower urinary tract (CAKUT) are poorly understood. To elucidate the molecular basis for signaling specificity of GDNF-mediated RET signaling in kidney development, we characterized mice that exclusively express either the human RET9 or RET51 isoform, or express these isoforms with individual mutations in docking tyrosines for PTB and...

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Identifiers

PMID: 16452504
DOI: 10.1101/gad.1387206
PMCID: PMC1361703

Genes

RET
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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