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Article

Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney Induction

26 Dec 2008

Abstract excerpt

Metanephric kidney induction critically depends on mesenchymal-epithelial interactions in the caudal region of the nephric (or Wolffian) duct. Central to this process, GDNF secreted from the metanephric mesenchyme induces ureter budding by activating the Ret receptor expressed in the nephric duct epithelium. A failure to regulate this pathway is believed to be responsible for a large proportion of the...

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PMID: 19112489
DOI: 10.1371/journal.pgen.1000316

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Gata3 Acts Downstream of β-Catenin Signaling to Prevent Ectopic Metanephric Kidney InductionPMID 19112489Read ↗

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