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Article

Loss of Sprouty1 rescues renal agenesis caused by Ret mutation.

Journal of the American Society of Nephrology : JASN - 1 Feb 2009

Rozen Esteban J, Schmidt Hagen, Dolcet Xavier, Basson M Albert, Jain Sanjay, Encinas Mario

Abstract excerpt

Renal morphogenesis requires a balance between positive and negative signals, which are provided in part by the receptor tyrosine kinase Ret and the putative tumor suppressor Sprouty1, respectively. Tyrosine 1062 of Ret is a binding site for several adaptor and effector proteins, such as Grb2/Sos/Ras, which activate the ERK pathway. Mice lacking Ret tyrosine 1062 nearly mimic the phenotype of Ret-knockout mice,...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19056869
DOI: 10.1681/ASN.2008030267
PMCID: PMC2637045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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