Neuroticism mediates the effect of P2RX7 on outcomes of mood disorders.

doi:10.1002/da.21945

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Article

Neuroticism mediates the effect of P2RX7 on outcomes of mood disorders.

Depression and anxiety - 1 Sept 2012

Mantere Outi, Soronen Pia, Uher Rudolf, Ketokivi Mikko, Jylhä Pekka, Melartin Tarja, Paunio Tiina, Isometsä Erkki

Abstract excerpt

BACKGROUND: We previously reported an association between P2RX7 variant rs208294, diagnosis, and the longitudinal course of mood disorders. Here, we test whether the personality trait neuroticism mediates the effect of P2RX7 on the course of mood disorders. METHODS: Patients with DSM-IV mood disorder (256 with major depressive disorder and 168 with bipolar disorder [BD]) were diagnosed with semistructured...

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PMID: 22623165
DOI: 10.1002/da.21945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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