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Article

The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism.

Journal of affective disorders - 15 Dec 2012

Mandelli Laura, Antypa Niki, Nearchou Finiki A, Vaiopoulos Chrysostomos, Stefanis Costas N, Serretti Alessandro, Stefanis Nikos C

Abstract excerpt

BACKGROUND: Depression is considered to be the result of a complicated synergy between genetic and environmental factors. Several genes of the serotonergic neurotransmission have been related to depression phenotypes, however results are inconsistent, possibly due to the oversight of the role of environmental stress. METHODS: We examined gene-environment (GxE) interactions with serotonergic genes on depressive...

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Identifiers

PMID: 22868061
DOI: 10.1016/j.jad.2012.03.047

Genes

TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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