Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2011

Soronen Pia, Mantere Outi, Melartin Tarja, Suominen Kirsi, Vuorilehto Maria, Rytsälä Heikki, Arvilommi Petri, Holma Irina, Holma Mikael, Jylhä Pekka, Valtonen Hanna M, Haukka Jari, Isometsä Erkki, Paunio Tiina

Abstract excerpt

We investigated the effect of nine candidate genes on risk for mood disorders, hypothesizing that predisposing gene variants not only elevate the risk for mood disorders but also result in clinically significant differences in the clinical course of mood disorders. We genotyped 178 DSM-IV bipolar I and II and 272 major depressive disorder patients from three independent clinical cohorts carefully diagnosed with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Mood Disorders

Share to Predictive Value of Tests

Share to Prognosis

Share to Receptors, Purinergic P2X7

Share to Treatment Outcome

Source

Identifiers

PMID: 21438144
DOI: 10.1002/ajmg.b.31179

Genes

BDNF
COMT
DAOA
DISC1
MAOA
NTRK2
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts.PMID 21438144Read ↗

Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes.Semantic proximity Read ↗

The P2RX7 polymorphism rs2230912 is associated with depression: A meta-analysis.Semantic proximity Read ↗

Neuroticism mediates the effect of P2RX7 on outcomes of mood disorders.Semantic proximity Read ↗

P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?Semantic proximity Read ↗

Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders.Semantic proximity Read ↗

Neuroplasticity, Neurotransmission and Brain-Related Genes in Major Depression and Bipolar Disorder: Focus on Treatment Outcomes in an Asiatic Sample.Semantic proximity Read ↗

Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis.Semantic proximity Read ↗

Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms.Semantic proximity Read ↗

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.Semantic proximity Read ↗

P2RX7 gene variation mediates the effect of childhood adversity and recent stress on the severity of depressive symptoms.Semantic proximity Read ↗

Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.Semantic proximity Read ↗

P2RX7: expression responds to sleep deprivation and associates with rapid cycling in bipolar disorder type 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.