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Article

Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression.

Neuropsychobiology - 1 Jan 2006

Munafò Marcus R, Clark Taane G, Roberts Kate H, Johnstone Elaine C

Abstract excerpt

BACKGROUND AND OBJECTIVES: An association between a polymorphism in the serotonin transporter gene (5HTT-LPR) and the personality trait of neuroticism has been reported. We sought to address the question of whether trait neuroticism mediates the putative association between this polymorphism and lifetime major depression in adults drawn from the general population. METHODS: Two hundred and fifty-one participants...

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PMID: 16319503
DOI: 10.1159/000089915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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