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Article

Causal influences of neuroticism on mental health and cardiovascular disease.

Human genetics - 1 Sept 2021

Zhang Fuquan, Baranova Ancha, Zhou Chao, Cao Hongbao, Chen Jiu, Zhang Xiangrong, Xu Mingqing

Abstract excerpt

We investigated the relationship between neuroticism and 16 mental and 18 physical traits using summary results of genome-wide association studies for these traits. LD score regression was used to investigate genetic correlations between neuroticism and the 34 health outcomes. Mendelian randomization was performed to investigate mutual causal relationships between neuroticism and the 34 health outcomes....

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Cardiovascular Diseases
Genetic Associations and Epidemiology
Genome-Wide Association Study
Mental Disorders
Mental Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait, Heritable

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PMID: 33973063
DOI: 10.1007/s00439-021-02288-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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