Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>Plasmodium falciparum</i> Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A <i>var</i> Genes

3 May 2004

Abstract excerpt

Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P. falciparum malaria. Parasites causing severe malaria in nonimmune patients tend to express a restricted subset of VSA (VSA(SM)) that differs from VSA associated with uncomplicated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Drug Transport and Resistance Mechanisms
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15123742
DOI: 10.1084/jem.20040274

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>Plasmodium falciparum</i> Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A <i>var</i> GenesPMID 15123742Read ↗

<i>Plasmodium falciparum</i> erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in childrenSemantic proximity Read ↗

Antigenic Variation in <i>Plasmodium falciparum</i> : Gene Organization and Regulation of the <i>var</i> Multigene FamilySemantic proximity Read ↗

Virulence of Malaria Is Associated with Differential Expression of<i>Plasmodium falciparum var</i>Gene Subgroups in a Case‐Control StudySemantic proximity Read ↗

Expression of specific <i>var</i> gene subtypes is differentially associated with severe malaria syndromesSemantic proximity Read ↗

<i>Plasmodium falciparum</i> expresses fewer <i>var</i> genes at lower levels during asymptomatic dry season infections than clinical malaria casesSemantic proximity Read ↗

Antigenic Variation in<i>Plasmodium falciparum</i>Semantic proximity Read ↗

A subset of group A-like <i>var</i> genes encodes the malaria parasite ligands for binding to human brain endothelial cellsSemantic proximity Read ↗

Evidence for the importance of genetic structuring to the structural and functional specialization of the <i>Plasmodium falciparum var</i> gene familySemantic proximity Read ↗

Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemiaSemantic proximity Read ↗

Repurposing of Plasmodium falciparum var genes beyond the blood stageSemantic proximity Read ↗

High diversity and rapid changeover of expressed <i>var</i> genes during the acute phase of <i>Plasmodium falciparum</i> infections in human volunteersSemantic proximity Read ↗

Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.