Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal Inhibitors

15 May 2012

Abstract excerpt

The pro-apoptotic p53 target Noxa is a BH3-only protein that antagonizes the function of selected anti-apoptotic Bcl-2 family members. While much is known regarding the transcriptional regulation of Noxa, its posttranscriptional regulation remains relatively unstudied. In this study, we therefore investigated whether Noxa is regulated by microRNAs. Using a screen combining luciferase reporters, bioinformatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22615771
DOI: 10.1371/journal.pone.0036490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal InhibitorsPMID 22615771Read ↗

Autophagy regulates apoptosis by targeting NOXA for degradationSemantic proximity Read ↗

Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancerSemantic proximity Read ↗

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomibSemantic proximity Read ↗

Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer.Semantic proximity Read ↗

Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein InhibitorsSemantic proximity Read ↗

BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced ApoptosisSemantic proximity Read ↗

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapiesSemantic proximity Read ↗

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.Semantic proximity Read ↗

DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex.Semantic proximity Read ↗

Mutational analysis of Noxa gene in human cancers.Semantic proximity Read ↗

In vitro binding properties of tumor suppressor p53 with PUMA and NOXA.Semantic proximity Read ↗

The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.