Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors

Abstract excerpt

Anti-apoptotic BCL-2 family proteins are frequently overexpressed in various cancers, playing a pivotal role in cancer initiation and progression, as well as intrinsic or acquired resistance to therapy. Although inhibitors targeting BCL-2, such as Venetoclax, have shown efficacy in hematological malignancies, their therapeutic potential in solid tumors remains limited. Identifying novel molecular targets to overco...

Topics

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• CAR-T cell therapy research
• Cell Adhesion Molecules Research
• Cell death mechanisms and regulation
• Chronic Lymphocytic Leukemia Research
• Cytokine Signaling Pathways and Interactions
• Protein Degradation and Inhibitors
• Protein Kinase Regulation and GTPase Signaling
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

2b9a5185-fd24-5402-b27b-f82c9a57eb95

DOI

10.1101/2024.04.24.590941