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Article

In vitro binding properties of tumor suppressor p53 with PUMA and NOXA.

Biochemical and biophysical research communications - 6 Apr 2012

Park So Young, Jeong Mi Suk, Jang Se Bok

Abstract excerpt

The p53-upregulated modulator of apoptosis (Puma) and Noxa, are direct targets in p53-mediated apoptosis localized to the mitochondria. Tumor suppressor p53 induces apoptosis by transcriptional induction of Puma and Noxa, which encode proapoptotic BH3-only member Bcl-1 family proteins. However, at a molecular level, the mechanism of action of Puma and Noxa proteins remain poorly defined. In addition, there have...

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Source

Identifiers

PMID: 22446329
DOI: 10.1016/j.bbrc.2012.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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