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Article

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

21 Aug 2014

Abstract excerpt

The c-MYC (MYC afterward) oncogene is well known for driving numerous oncogenic programs. However, MYC can also induce apoptosis and this function of MYC warrants further clarification. We report here that a clinically relevant proteasome inhibitor significantly increases MYC protein levels and that endogenous MYC is necessary for the induction of apoptosis. This kind of MYC-induced cell death is mediated by...

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PMID: 25147211
DOI: 10.1093/nar/gku763

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Related research

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Research trail→

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MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomibPMID 25147211Read ↗

BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid TissuesSemantic proximity Read ↗

Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancerSemantic proximity Read ↗

PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expressionSemantic proximity Read ↗

MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal InhibitorsSemantic proximity Read ↗

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.Semantic proximity Read ↗

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancerSemantic proximity Read ↗

Up-regulation of Bcl-2 Homology 3 (BH3)-only Proteins by E2F1 Mediates ApoptosisSemantic proximity Read ↗

Egr1 mediates p53-independent c-Myc–induced apoptosis via a noncanonical ARF-dependent transcriptional mechanismSemantic proximity Read ↗

Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic PathwaySemantic proximity Read ↗

Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses.Semantic proximity Read ↗

KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cellsSemantic proximity Read ↗

MNT loss in MYC-driven B lymphoma cells enhances apoptosis, inhibits proliferation and increases sensitivity to cancer drugsSemantic proximity Read ↗

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