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Article

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

14 Nov 2019

Abstract excerpt

Most targeted cancer therapies fail to achieve complete tumor regressions or attain durable remissions. To understand why these treatments fail to induce robust cytotoxic responses despite appropriately targeting oncogenic drivers, here we systematically interrogated the dependence of cancer cells on the BCL-2 family of apoptotic proteins after drug treatment. We observe that multiple targeted therapies,...

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PMID: 31727958
DOI: 10.1038/s41467-019-12477-y

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