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Article

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.

Cell death and differentiation - 1 May 2009

Michalak E M, Jansen E S, Happo L, Cragg M S, Tai L, Smyth G K, Strasser A, Adams J M, Scott C L

Abstract excerpt

Evasion of apoptosis contributes importantly to c-Myc-induced tumorigenesis. The BH3-only Bcl-2 family members Puma and Noxa are critical pro-apoptotic transcriptional targets of p53, a major mediator of Myc-induced apoptosis and suppressor of Myc-induced tumorigenesis. Hence, we have explored the impact of their individual or combined loss on myc-driven lymphomagenesis. Notably, Puma deficiency both increased...

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Share to Apoptosis Regulatory Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, B-Cell

Share to Precursor Cells, B-Lymphoid

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Share to Tumor Suppressor Protein p53

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Source

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Identifiers

PMID: 19148184
DOI: 10.1038/cdd.2008.195
PMCID: PMC2743939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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