Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells.

Leukemia & lymphoma - 1 Dec 2013

Zhu Hai-Jia, Liu Ling, Fan Lei, Zhang Li-Na, Fang Cheng, Zou Zhi-Jian, Li Jian-Yong, Xu Wei

Abstract excerpt

The purpose of this study was to explore the characteristics and functions of BH3-only proteins Puma, Noxa and Bim in the prognosis, therapy and drug resistance of chronic lymphocytic leukemia (CLL). Puma, Noxa and Bim mRNAs were evaluated by real-time quantitative reverse transcriptase-polymerase chain reaction, and correlations between their expression levels and CLL prognostic markers were analyzed. Primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-ribosyl Cyclase 1
Share to Bcl-2-Like Protein 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Immunoglobulin Heavy Chains

Share to Mitochondrial Membrane Transport Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Share to Vidarabine

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 23517560
DOI: 10.3109/10428194.2013.787613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The BH3-only protein Puma plays an essential role in p53-mediated apoptosis of chronic lymphocytic leukemia cells.PMID 23517560Read ↗

Puma, a critical mediator of cell death — one decade on from its discoverySemantic proximity Read ↗

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.Semantic proximity Read ↗

BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced ApoptosisSemantic proximity Read ↗

Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profilingSemantic proximity Read ↗

Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl‐2 family1Semantic proximity Read ↗

Indirubin in Vitro Apoptotic Effect Towards Chronic Lymphocytic Leukaemia (CLL) LineageSemantic proximity Read ↗

MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteinsSemantic proximity Read ↗

Quantitative real time PCR analysis of apoptotic gene expression in chronic lymphocytic leukemia patients and their relationships with chemosensitivitySemantic proximity Read ↗

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia.Semantic proximity Read ↗

MiR-200c Regulates Noxa Expression and Sensitivity to Proteasomal InhibitorsSemantic proximity Read ↗

Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family membersSemantic proximity Read ↗

Regulation of BNIP3 in Normal and Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.