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Article

Exploiting the pro-apoptotic function of NOXA as a therapeutic modality in cancer

3 Jul 2017

Abstract excerpt

INTRODUCTION: Direct targeting of Bcl-2 members for therapeutic purposes in cancer has become a clinical reality with the FDA approval of ABT-199/Venetoclax. Other highly specific BH3-mimetics are in pre-clinical development. Understanding the functional interactions among the Bcl-2 family is of prime importance to fully exploit their potential. NOXA is considered a rather weak BH3-only member but it has...

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PMID: 28670929
DOI: 10.1080/14728222.2017.1349754

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