Article
Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation.
The Journal of biological chemistry - 6 Jul 2012
Bogan Jonathan S, Rubin Bradley R, Yu Chenfei, Löffler Michael G, Orme Charisse M, Belman Jonathan P, McNally Leah J, Hao Mingming, Cresswell James A
Abstract excerpt
To promote glucose uptake into fat and muscle cells, insulin causes the translocation of GLUT4 glucose transporters from intracellular vesicles to the cell surface. Previous data support a model in which TUG traps GLUT4-containing vesicles and tethers them intracellularly in unstimulated cells and in which insulin mobilizes this pool of vesicles by releasing this tether. Here we show that TUG undergoes...
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