Article
Deciphering the role of GLUT4 N-glycosylation in adipocyte and muscle cell models.
The Biochemical journal - 15 Jul 2012
Zaarour Nancy, Berenguer Marion, Le Marchand-Brustel Yannick, Govers Roland
Abstract excerpt
GLUT4 (glucose transporter 4) is responsible for the insulin-induced uptake of glucose by muscle and fat cells. In non-stimulated (basal) cells, GLUT4 is retained intracellularly, whereas insulin stimulation leads to its translocation from storage compartments towards the cell surface. How GLUT4 is retained intracellularly is largely unknown. Previously, aberrant GLUT4 N-glycosylation has been linked to increased...
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