Article
Munc18c depletion selectively impairs the sustained phase of insulin release.
Diabetes - 1 May 2009
Oh Eunjin, Thurmond Debbie C
Abstract excerpt
OBJECTIVE: The Sec1/Munc18 protein Munc18c has been implicated in Syntaxin 4-mediated exocytosis events, although its purpose in exocytosis has remained elusive. Given that Syntaxin 4 functions in the second phase of glucose-stimulated insulin secretion (GSIS), we hypothesized that Munc18c would also be required and sought insight into the possible mechanism(s) using the islet beta-cell as a model system....
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