Article

Clathrin differentially adapts its trimerisation domain during mammalian evolution to traffic the insulin-responsive GLUT4 glucose transporter.

2026-08-21

Abstract excerpt

In humans, the CHC22 isoform of clathrin regulates glucose metabolism by trafficking the GLUT4 glucose transporter for intracellular storage in skeletal muscle and release following insulin signalling. Some vertebrate lineages have lost the gene encoding CHC22 but operate the same insulin-stimulated GLUT4 expression pathway. Here, we show that species lacking CHC22 exclusively produce an alternatively-spliced form...

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Literature Corpus work: 14495a4e-3b13-5cba-a831-1647671bdf7c
DOI: 10.64898/2026.08.20.745084

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Clathrin differentially adapts its trimerisation domain during mammalian evolution to traffic the insulin-responsive GLUT4 glucose transporter.DOI 10.64898/2026.08.20.745084Read

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