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Article

Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.

The Journal of biological chemistry - 5 Sept 2014

Bhatnagar Sushant, Soni Mufaddal S, Wrighton Lindsay S, Hebert Alexander S, Zhou Amber S, Paul Pradyut K, Gregg Trillian, Rabaglia Mary E, Keller Mark P, Coon Joshua J, Attie Alan D

Abstract excerpt

The abundance and functional activity of proteins involved in the formation of the SNARE complex are tightly regulated for efficient exocytosis. Tomosyn proteins are negative regulators of exocytosis. Tomosyn causes an attenuation of insulin secretion by limiting the formation of the SNARE comple...

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Identifiers

PMID: 25002582
DOI: 10.1074/jbc.M114.575985
PMCID: PMC4155689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25002582-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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