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Article

Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking.

Science signaling - 21 Mar 2017

Uhm Maeran, Bazuine Merlijn, Zhao Peng, Chiang Shian-Huey, Xiong Tingting, Karunanithi Sheelarani, Chang Louise, Saltiel Alan R

Abstract excerpt

Insulin stimulates glucose uptake through the translocation of the glucose transporter GLUT4 to the plasma membrane. The exocyst complex tethers GLUT4-containing vesicles to the plasma membrane, a process that requires the binding of the G protein (heterotrimeric guanine nucleotide-binding protein) RalA to the exocyst complex. We report that upon activation of RalA, the protein kinase TBK1 phosphorylated the...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28325821
DOI: 10.1126/scisignal.aah5085

Genes

TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking.PMID 28325821Read ↗

Insulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering.Semantic proximity Read ↗

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cellsSemantic proximity Read ↗

Mitotic phosphorylation of Exo84 disrupts exocyst assembly and arrests cell growth.Semantic proximity Read ↗

Exosome Trafficking Is a Key Regulator of Adipocyte ThermogenesisSemantic proximity Read ↗

Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells.Semantic proximity Read ↗

ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70.Semantic proximity Read ↗

Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation.Semantic proximity Read ↗

Expression of a synapsin IIb site 1 phosphorylation mutant in 3T3-L1 adipocytes inhibits basal intracellular retention of Glut4.Semantic proximity Read ↗

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.Semantic proximity Read ↗

Syntaxin 16 controls the intracellular sequestration of GLUT4 in 3T3-L1 adipocytes.Semantic proximity Read ↗

Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.Semantic proximity Read ↗

GLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistance.Semantic proximity Read ↗

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