Article
Unconventional secretion of tubby and tubby-like protein 1.
FEBS letters - 17 Sept 2009
Caberoy Nora B, Li Wei
Abstract excerpt
Tubby-like proteins (Tulps) with no signal peptide have been characterized as cytoplasmic proteins with various intracellular functions, including binding to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2)]. PI(4,5)P(2) has been implicated in unconventional secretion of fibroblast growth factor-2 without a signal peptide. Here, we show that all Tulps are expressed intracellularly and extracellularly. Tubby...
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