Article
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation.
The Journal of cell biology - 20 Aug 2001
Watson R T, Shigematsu S, Chiang S H, Mora S, Kanzaki M, Macara I G, Saltiel A R, Pessin J E
Abstract excerpt
Recent studies indicate that insulin stimulation of glucose transporter (GLUT)4 translocation requires at least two distinct insulin receptor-mediated signals: one leading to the activation of phosphatidylinositol 3 (PI-3) kinase and the other to the activation of the small GTP binding protein TC10. We now demonstrate that TC10 is processed through the secretory membrane trafficking system and localizes to...
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