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Article

O-glycosylation regulates polarized secretion by modulating Tango1 stability.

Proceedings of the National Academy of Sciences of the United States of America - 20 May 2014

Zhang Liping, Syed Zulfeqhar Ali, van Dijk Härd Iris, Lim Jae-Min, Wells Lance, Ten Hagen Kelly G

Abstract excerpt

Polarized secretion is crucial in many tissues. The conserved protein modification, O-glycosylation, plays a role in regulating secretion. However, the mechanisms by which this occurs are unknown. Here, we demonstrate that an O-glycosyltransferase functions as a novel regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein, Tango1...

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Identifiers

PMID: 24799692
DOI: 10.1073/pnas.1322264111
PMCID: PMC4034226

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