Article
Single nucleotide polymorphisms in sFRP4 are associated with bone and body composition related parameters in Danish but not in Belgian men.
Molecular genetics and metabolism - 1 Jul 2012
Boudin Eveline, Piters Elke, Nielsen Torben Leo, Andersen Marianne, Roef Greet, Taes Youri, Brixen Kim, Van Hul Wim
Abstract excerpt
The senescence accelerated mouse P6 (SAMP6) has a low bone mass and has previously shown to be a good model for senile osteoporosis in humans. In addition to a reduced bone mass, SAMP6 mice are obese and have hyperlipidemia. Using positional cloning and expression studies, an increased expression of sfrp4 was found in these mice. SFRP4 is a modulator of the Wnt signalling pathway. This pathway has been previously...
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