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Article

Mutations in sFRP1 or sFRP4 are not a common cause of craniotubular hyperostosis.

Bone - 1 Jan 2013

Boudin Eveline, Piters Elke, Fijalkowski Igor, Stevenheydens Gino, Steenackers Ellen, Kuismin Outi, Moilanen Jukka S, Mortier Geert, Van Hul Wim

Abstract excerpt

Sclerosing bone dysplasias are a heterogeneous group of rare diseases marked by increased BMD caused by either increased bone formation or by decreased bone resorption. In this study we have focused on craniotubular hyperostoses mainly affecting the long bones and the skull. Currently, there are three causative genes identified namely LRP5, SOST and LRP4. All three genes are involved in the canonical Wnt...

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Source

Identifiers

PMID: 23044044
DOI: 10.1016/j.bone.2012.09.034

Genes

LRP4
LRP5
SOST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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