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Article

Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population.

Calcified tissue international - 1 Dec 2009

Mencej-Bedrac Simona, Prezelj Janez, Kocjan Tomaz, Komadina Radko, Marc Janja

Abstract excerpt

The Wnt pathway has a bifunctional role in bone mass regulation, influencing osteoblasts and osteoclasts. The Wnt pathway genes are therefore candidate genes for susceptibility to osteoporosis. In our study, we focused on the effects of polymorphisms in selected Wnt pathway genes: low-density lipoprotein receptor-related proteins 5 and 6 (LRP5 and LRP6), Dickkopf1 (DKK1), sclerostin (SOST), and beta-catenin...

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Source

Identifiers

PMID: 19898734
DOI: 10.1007/s00223-009-9306-y

Genes

SOST
CTNNB1
DKK1
LRP5
LRP6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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