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Article

Association study of common variants in the sFRP1 gene region and parameters of bone strength and body composition in two independent healthy Caucasian male cohorts.

Molecular genetics and metabolism - 1 Mar 2012

Boudin Eveline, Piters Elke, Fransen Erik, Nielsen Torben Leo, Andersen Marianne, Roef Greet, Taes Youri, Brixen Kim, Van Hul Wim

Abstract excerpt

Bone mineral density (BMD) and bone strength are predictive parameters for the development of osteoporosis and related fracture later in life. Although it is well known that BMD and bone strength have a high heritability, not much of the variation is already explained. Mice models showed that sFRP1 has an influence on bone formation. Therefore this study aimed to investigate the effect of common genetic variation...

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PMID: 22178351
DOI: 10.1016/j.ymgme.2011.11.189

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