Article
A genome-wide association analysis implicates SOX6 as a candidate gene for wrist bone mass.
Science China. Life sciences - 1 Sept 2010
Tan LiJun, Liu Rong, Lei ShuFeng, Pan Rong, Yang TieLin, Yan Han, Pei YuFang, Yang Fang, Zhang Feng, Pan Feng, Zhang YinPin, Hu HongGang, Levy Shawn, Deng HongWen
Abstract excerpt
Osteoporosis is a highly heritable common bone disease leading to fractures that severely impair the life quality of patients. Wrist fractures caused by osteoporosis are largely due to the scarcity of wrist bone mass. Here we report the results of a genome-wide association study (GWAS) of wrist bone mineral density (BMD). We examined ∼500000 SNP markers in 1000 unrelated homogeneous Caucasian subjects and found a...
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