PPARG by dietary fat interaction influences bone mass in mice and humans.

doi:10.1359/jbmr.080419

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

PPARG by dietary fat interaction influences bone mass in mice and humans.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2008

Ackert-Bicknell Cheryl L, Demissie Serkalem, Marín de Evsikova Caralina, Hsu Yi-Hsiang, DeMambro Victoria E, Karasik David, Cupples L Adrienne, Ordovas Jose M, Tucker Katherine L, Cho Kelly, Canalis Ernesto, Paigen Beverly, Churchill Gary A, Forejt Jiri, Beamer Wesley G, Ferrari Serge, Bouxsein Mary L, Kiel Douglas P, Rosen Clifford J

Abstract excerpt

Adult BMD, an important risk factor for fracture, is the result of genetic and environmental interactions. A quantitative trait locus (QTL) for the phenotype of volumetric BMD (vBMD), named Bmd8, was found on mid-distal chromosome (Chr) 6 in mice. This region is homologous to human Chr 3p25. The B6.C3H-6T (6T) congenic mouse was previously created to study this QTL. Using block haplotyping of the 6T congenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Composition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone and Bones

Share to Dietary Fats

Share to Mice, Inbred C3H

Share to Organ Size

Share to Osteoporosis

Share to PPAR gamma

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 18707223
DOI: 10.1359/jbmr.080419
PMCID: PMC2683155

Genes

PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPARG by dietary fat interaction influences bone mass in mice and humans.PMID 18707223Read ↗

Congenic mice provide in vivo evidence for a genetic locus that modulates intrinsic transforming growth factor β1-mediated signaling and bone acquisition.Semantic proximity Read ↗

Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density.Semantic proximity Read ↗

Quantitative trait loci affecting peak bone mineral density in mice.Semantic proximity Read ↗

Two novel quantitative trait loci on mouse chromosomes 6 and 4 independently and synergistically regulate plasma apoB levels.Semantic proximity Read ↗

Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice.Semantic proximity Read ↗

A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density.Semantic proximity Read ↗

Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background.Semantic proximity Read ↗

Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross.Semantic proximity Read ↗

Chromosome 13 locus, Pbd2, regulates bone density in mice.Semantic proximity Read ↗

A novel locus on the X chromosome regulates post-maturity bone density changes in mice.Semantic proximity Read ↗

Identification of gender-specific candidate genes that influence bone microarchitecture in chromosome 1.Semantic proximity Read ↗

Multiple quantitative trait loci for cortical and trabecular bone regulation map to mid-distal mouse chromosome 4 that shares linkage homology to human chromosome 1p36.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.