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Article

Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2013

Rodríguez-Rodríguez E, Sánchez-Juan P, Vázquez-Higuera J L, Mateo I, Pozueta A, Berciano J, Cervantes S, Alcolea D, Martínez-Lage P, Clarimón J, Lleó A, Pastor P, Combarros O

Abstract excerpt

Aside from APOE, the genetic factors that influence the progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD) remain largely unknown. We assessed whether a genetic risk score (GRS), based on eight non-APOE genetic variants previously associated with AD risk in genome-wide association studies, is associated with either risk of conversion or with rapid progression from MCI to AD. Among 288...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23180304
DOI: 10.1007/s00702-012-0920-x

Genes

APOE
ABCA7
BIN1
CLU
PICALM

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