Article
Tissue-based predictors of germ-line BRCA1 mutations: implications for triaging of genetic testing.
Human pathology - 1 Nov 2012
de la Cruz Jeannine, Andre Fabrice, Harrell Robyn K, Bassett Roland L, Arun Banu, Mathieu Marie-Christine, Delaloge Suzette, Gilcrease Michael Z
Abstract excerpt
BRCA testing of patients with breast cancer considered at high risk for having a germ-line BRCA mutation usually consists of comprehensive mutational analysis of both BRCA1 and BRCA2. A more cost-effective strategy of triaging patients for analysis of a single gene could be adopted if tissue-based predictors indicated a high risk specifically for either BRCA1 or BRCA2. To identify potentially useful tissue-based...
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