Article
Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2012
Soslow Robert A, Han Guangming, Park Kay J, Garg Karuna, Olvera Narciso, Spriggs David R, Kauff Noah D, Levine Douglas A
Abstract excerpt
This study was undertaken with the hypothesis that certain common morphologic features of ovarian carcinomas are predictably associated with BRCA1 and BRCA2 deficiencies. We selected 43 high-grade serous carcinomas diagnosed at Memorial Sloan-Kettering Cancer Center that were studied as part of The Cancer Genome Atlas pilot project. In addition to 12 randomly selected nonfamilial BRCA-unassociated cases, all 31...
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