Article
Basal cytokeratin and epidermal growth factor receptor expression are not predictive of BRCA1 mutation status in women with triple-negative breast cancers.
The American journal of surgical pathology - 1 Jul 2009
Collins Laura C, Martyniak Anthony, Kandel Michaela J, Stadler Zsofia K, Masciari Serena, Miron Alexander, Richardson Andrea L, Schnitt Stuart J, Garber Judy E
Abstract excerpt
BACKGROUND: Over 80% of breast cancers in women with germline BRCA1 mutations are estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2-negative ("triple negative") and most of these have a basal-like phenotype by expression profiling and immunophenotypic analysis. However, whether or not expression of biomarkers characteristic of basal-like breast cancers helps to define a subset...
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