Article
Morphology of breast cancer as a means of triage of patients for BRCA1 genetic testing.
The American journal of surgical pathology - 1 Nov 2006
Farshid Gelareh, Balleine Rosemary L, Cummings Margaret, Waring Paul
Abstract excerpt
BACKGROUND: Women who have germline mutations in the BRCA1 gene are at substantially increased lifetime risk of developing breast and ovarian cancer but are otherwise normal. Currently, early age of onset of cancer and a strong family history are relied upon as the chief clues as to who should be offered genetic testing. Certain morphologic and immunohistochemical features are overrepresented in BRCA1-associated...
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