Article
Incorporating tumour pathology information into breast cancer risk prediction algorithms.
Breast cancer research : BCR - 1 Jan 2010
Mavaddat Nasim, Rebbeck Timothy R, Lakhani Sunil R, Easton Douglas F, Antoniou Antonis C
Abstract excerpt
INTRODUCTION: Mutations in BRCA1 and BRCA2 confer high risks of breast cancer and ovarian cancer. The risk prediction algorithm BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm) may be used to compute the probabilities of carrying mutations in BRCA1 and BRCA2 and help to target mutation screening. Tumours from BRCA1 and BRCA2 mutation carriers display distinctive...
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