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Incorporating tumor immunohistochemical markers in BRCA1 and BRCA2 carrier prediction

20 Mar 2008

Abstract excerpt

Recent studies have demonstrated that histopathologic features of inherited breast cancers due to BRCA1 gene mutations often differ from those of sporadic breast cancer and from breast cancers caused by germline BRCA2 mutations. Invasive breast carcinomas in individuals with germline BRCA1 gene mutations tend to be of higher grade, either basal-type or basal-like, estrogen receptor (ER) negative, progesterone...

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PMID: 18466632
DOI: 10.1186/bcr1866

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