Article
Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jun 2009
Silva A M, Bettencourt A, Pereira C, Santos E, Carvalho C, Mendonça D, Costa P P, Monteiro L, Martins B
Abstract excerpt
BACKGROUND: Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA-DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA-A*02 and A*03 alleles has been described. OBJECTIVES: We examined the influence of HLA-A*02 and HLA-A*03 in Portuguese patients with MS, independently of HLA-DRB1*15 using a logistic regression...
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