Article
Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease.
Tissue antigens - 1 Feb 2000
Fogdell-Hahn A, Ligers A, Grønning M, Hillert J, Olerup O
Abstract excerpt
Multiple sclerosis (MS) is a presumed autoimmune disease of the central nervous system, shown to be associated with the HLA class II haplotype DRB1*15,DQB1*06. Carrying the HLA class II haplotype DRB1*15,DQB1*06 increases the risk of MS by 3.6. By adopting a polymerase chain reaction (PCR)-based typing technique for HLA class I and class II genes, 200 Swedish MS patients and 210 Swedish healthy controls were...
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