Article
Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients.
Scientific reports - 17 Apr 2018
Guo Fang, Gong Hai, Zhao Huanhuan, Chen Jing, Zhang Yiming, Zhang Lihua, Shi Xin, Zhang Aifeng, Jin Hui, Zhang Jianqiong, He Youji
Abstract excerpt
Mutations in KRAS exon 2, BRAF and PIK3CA are commonly present in colorectal cancer (CRC) worldwide, but few data about RAS mutations outside KRAS exon 2 are available for Chinese CRCs. We, therefore, determined the mutation frequencies and prognostic values of KRAS exon 2, 3 and 4, NRAS exon 2 and 3, PIK3CA exon 9 and 20, and BRAF exon 15 by PCR and direct sequencing in 353 CRC patients from two Chinese clinical...
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