Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma.

doi:10.1158/2159-8290.CD-11-0246

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Article

Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma.

Cancer discovery - 1 Feb 2012

Shi Jianxin, Chatterjee Nilanjan, Rotunno Melissa, Wang Yufei, Pesatori Angela C, Consonni Dario, Li Peng, Wheeler William, Broderick Peter, Henrion Marc, Eisen Timothy, Wang Zhaoming, Chen Wei, Dong Qiong, Albanes Demetrius, Thun Michael, Spitz Margaret R, Bertazzi Pier Alberto, Caporaso Neil E, Chanock Stephen J, Amos Christopher I, Houlston Richard S, Landi Maria Teresa

Abstract excerpt

UNLABELLED: Although lung cancer is largely caused by tobacco smoking, inherited genetic factors play a role in its etiology. Genome-wide association studies in Europeans have only robustly demonstrated 3 polymorphic variations that influence the risk of lung cancer. Tumor heterogeneity may have hampered the detection of association signal when all lung cancer subtypes were analyzed together. In a genome-wide...

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Identifiers

PMID: 22585858
DOI: 10.1158/2159-8290.CD-11-0246
PMCID: PMC3354721

Genes

RAD52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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