Article
The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract.
PloS one - 1 Jan 2015
Delahaye-Sourdeix Manon, Oliver Javier, Timofeeva Maria N, Gaborieau Valérie, Johansson Mattias, Chabrier Amélie, Wozniak Magdalena B, Brenner Darren R, Vallée Maxime P, Anantharaman Devasena, Lagiou Pagona, Holcátová Ivana, Richiardi Lorenzo, Kjaerheim Kristina, Agudo Antonio, Castellsagué Xavier, Macfarlane Tatiana V, Barzan Luigi, Canova Cristina, Thakker Nalin S, Conway David I, Znaor Ariana, Healy Claire M, Ahrens Wolfgang, Zaridze David, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Fabianova Eleonora, Mates Ioan Nicolae, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Curado Maria Paula, Koifman Sergio, Menezes Ana, Wünsch-Filho Victor, Eluf-Neto José, Boffetta Paolo, Garrote Leticia Fernández, Serraino Diego, Lener Marcin, Jaworowska Ewa, Lubiński Jan, Boccia Stefania, Rajkumar Thangarajan, Samant Tanuja A, Mahimkar Manoj B, Matsuo Keitaro, Franceschi Silvia, Byrnes Graham, Brennan Paul, McKay James D
Abstract excerpt
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified...
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