Article
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
American journal of human genetics - 1 Nov 2009
Landi Maria Teresa, Chatterjee Nilanjan, Yu Kai, Goldin Lynn R, Goldstein Alisa M, Rotunno Melissa, Mirabello Lisa, Jacobs Kevin, Wheeler William, Yeager Meredith, Bergen Andrew W, Li Qizhai, Consonni Dario, Pesatori Angela C, Wacholder Sholom, Thun Michael, Diver Ryan, Oken Martin, Virtamo Jarmo, Albanes Demetrius, Wang Zhaoming, Burdette Laurie, Doheny Kimberly F, Pugh Elizabeth W, Laurie Cathy, Brennan Paul, Hung Rayjean, Gaborieau Valerie, McKay James D, Lathrop Mark, McLaughlin John, Wang Ying, Tsao Ming-Sound, Spitz Margaret R, Wang Yufei, Krokan Hans, Vatten Lars, Skorpen Frank, Arnesen Egil, Benhamou Simone, Bouchard Christine, Metspalu Andres, Metsapalu Andres, Vooder Tonu, Nelis Mari, Välk Kristian, Field John K, Chen Chu, Goodman Gary, Sulem Patrick, Thorleifsson Gudmar, Rafnar Thorunn, Eisen Timothy, Sauter Wiebke, Rosenberger Albert, Bickeböller Heike, Risch Angela, Chang-Claude Jenny, Wichmann H Erich, Stefansson Kari, Houlston Richard, Amos Christopher I, Fraumeni Joseph F, Savage Sharon A, Bertazzi Pier Alberto, Tucker Margaret A, Chanock Stephen, Caporaso Neil E
Abstract excerpt
Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study...
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