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Article

Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.

American journal of human genetics - 4 Sept 2025

Betti Michael J, Jaworski James, Zhao Shilin, Rao J Sunil, Ryan Bríd M, Schwartz Ann G, Lusk Christine M, McCoy Lucie, Wiencke John K, Bruce Marino A, Chanock Stephen, Gamazon Eric R, Hellwege Jacklyn N, Aldrich Melinda C

Abstract excerpt

Striking disparities in lung cancer exist, with Black/African American individuals disproportionately affected by lung cancer, yet the genetic architecture in African ancestry individuals is poorly understood. We aimed to address this by performing a comprehensive genetic association study of lung cancer, incorporating local ancestry, across 6,490 African ancestry individuals (2,390 individuals with lung cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40829600
DOI: 10.1016/j.ajhg.2025.07.009
PMCID: PMC12461003

Genes

ADK
CCDC12
CHRNA3
EML4
PSMA4
SNRNP200
TMEM50A
ZYG11A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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