Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers.

doi:10.1158/1055-9965.EPI-12-0352-T

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Multistage analysis of variants in the inflammation pathway and lung cancer risk in smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2012

Spitz Margaret R, Gorlov Ivan P, Dong Qiong, Wu Xifeng, Chen Wei, Chang David W, Etzel Carol J, Caporaso Neil E, Zhao Yang, Christiani David C, Brennan Paul, Albanes Demetrius, Shi Jianxin, Thun Michael, Landi Maria Teresa, Amos Christopher I

Abstract excerpt

BACKGROUND: Tobacco-induced lung cancer is characterized by a deregulated inflammatory microenvironment. Variants in multiple genes in inflammation pathways may contribute to risk of lung cancer. METHODS: We therefore conducted a three-stage comprehensive pathway analysis (discovery, replication, and meta-analysis) of inflammation gene variants in ever-smoking lung cancer cases and controls. A discovery set...

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PMID: 22573796
DOI: 10.1158/1055-9965.EPI-12-0352-T
PMCID: PMC3487592

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