Article
Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.
Nature communications - 7 Jan 2020
Kachuri Linda, Johansson Mattias, Rashkin Sara R, Graff Rebecca E, Bossé Yohan, Manem Venkata, Caporaso Neil E, Landi Maria Teresa, Christiani David C, Vineis Paolo, Liu Geoffrey, Scelo Ghislaine, Zaridze David, Shete Sanjay S, Albanes Demetrius, Aldrich Melinda C, Tardón Adonina, Rennert Gad, Chen Chu, Goodman Gary E, Doherty Jennifer A, Bickeböller Heike, Field John K, Davies Michael P, Dawn Teare M, Kiemeney Lambertus A, Bojesen Stig E, Haugen Aage, Zienolddiny Shanbeh, Lam Stephen, Le Marchand Loïc, Cheng Iona, Schabath Matthew B, Duell Eric J, Andrew Angeline S, Manjer Jonas, Lazarus Philip, Arnold Susanne, McKay James D, Emami Nima C, Warkentin Matthew T, Brhane Yonathan, Obeidat Ma'en, Martin Richard M, Relton Caroline, Davey Smith George, Haycock Philip C, Amos Christopher I, Brennan Paul, Witte John S, Hung Rayjean J
Abstract excerpt
Impaired lung function is often caused by cigarette smoking, making it challenging to disentangle its role in lung cancer susceptibility. Investigation of the shared genetic basis of these phenotypes in the UK Biobank and International Lung Cancer Consortium (29,266 cases, 56,450 controls) shows that lung cancer is genetically correlated with reduced forced expiratory volume in one second (FEV1: rg = 0.098,...
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