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Article

Glc-6-PD and PKG contribute to hypoxia-induced decrease in smooth muscle cell contractile phenotype proteins in pulmonary artery.

American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2012

Chettimada Sukrutha, Rawat Dhwajbahadur K, Dey Nupur, Kobelja Robert, Simms Zachary, Wolin Michael S, Lincoln Thomas M, Gupte Sachin A

Abstract excerpt

Persistent hypoxic pulmonary vasoconstriction (HPV) plays a significant role in the pathogenesis of pulmonary hypertension, which is an emerging clinical problem around the world. We recently showed that hypoxia-induced activation of glucose-6-phosphate dehydrogenase (Glc-6-PD) in pulmonary artery smooth muscle links metabolic changes within smooth muscle cells to HPV and that inhibition of Glc-6PD reduces acute...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glucosephosphate Dehydrogenase

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Share to Myocytes, Smooth Muscle

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Source

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Identifiers

PMID: 22582112
DOI: 10.1152/ajplung.00002.2012
PMCID: PMC3426433

Genes

VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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